Longitudinal study to explore chronic neuropsychologic effects on solvent exposed workers.

AIM The aim of the study was to examine possible neurotoxic effects on the central nervous system (CNS) in relation to a chronic solvent exposure at the workplace. METHOD The collective included 127 workers exposed to solvent mixtures, such as spray painters and printers. They were examined twice by means of a physical examination, neuropsychological testbattery, biological and air monitoring. RESULTS Major component of the solvents were white spirits in concentrations up to 127 ppm in air and 2,666 microg/l in blood. Single substances were mainly toluene and xylenes in concentrations below current threshold values at the workplace. During the 2 yr interval, the concentrations of solvents decreased, and no significant associations between the neuropsychological tests and the solvent exposure were found. Regarding the whole working history of each participant, we found a significant reduction on information processing velocity and performance in the trailmaking test, as well as more complaints of workers with higher solvent exposure in the past. CONCLUSIONS A slight increase of subjective complaints and a deteriorated power of concentration seems to be associated with chronic solvent exposure.